The prevalence of vitamin D deficiency is high in patients with chronic kidney disease (CKD).Vitamin D deficiency is associated with various bone disorders such as osteoporosis by affecting bone mineralization.Current international guidelines recommend vitamin D supplementation in CKD as well as in the general population.
However, the effect of various forms of vitamin D on bone health in CKD remains unclear.Few randomized controlled studies have evaluated the effects of vitamin D supplementation on bone Automotive Test Equipment mineral density and bone turnover markers; however, the findings of these studies are heterogeneous.This review aimed to present comprehensive and current findings on the effects of native vitamin D supplementation on bone biomarkers and bone mineral density in CKD.
We infered that native vitamin D treatment could improve some bone biomarkers, particularly in predialysis CKD patients with severe vitamin D deficiency.Our findings also draw attention to the fact that vitamin D is an important factor in treatment.However, it is essential to design better-quality and comprehensive controlled studies King Bookcase Bed to obtain clear findings.